Diastereo- and Enantioselective Synthesis of Functionalized β-Lactams from Oxiranecarbaldimines and Lithium Ester Enolates
✍ Scribed by Kristin Michel; Roland Fröhlich; Ernst-Ulrich Würthwein
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 341 KB
- Volume
- 2009
- Category
- Article
- ISSN
- 1434-193X
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## Abstract The reaction proceeds with high anti‐selectivity affording a wide range of the enantioenriched adducts.
## Abstract Alkylphenyl sulfones **3** are appropriate synthons for the synthesis of 2‐phenylsulfonyl alkylidene pyrro‐lidine or piperidine derivatives **1** in good to moderate yields. The lithium alkyl sulfones **4** are first reacted with the desired protected lactams and then subjected to acidi
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