Highly Diastereo- and Enantioselective S
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Dieter Enders; Thomas Hundertmark; Cornelia Lampe; Udo Jegelka; Ilse Scharfbilli
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Article
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1998
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John Wiley and Sons
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English
⚖ 229 KB
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An efficient asymmetric synthesis of protected anti-1,3-diols by reduction of the ketones 2 and a variant of the Barton-McCombie deoxygenation. The new method allows the 5 (de Ն 98%, ee = 92-98%) from 2,2-dimethyl-1,3-dioxan-5one SAMP hydrazone 1 is described. The key steps are the synthesis of acet