Diamond-Blackfan anemia and malignancy: A case report and a review of the literature

✍ Scribed by Riccardo Haupt; Carlo Dufour; Sandro Dallorso; Pier Giorgio Mori

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 203 KB
• Volume: 77
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19960501)77:9<1961::aid-cncr35>3.0.co;2-w

✦ Synopsis

s one of the authors reports in a comprehensive review , I nephrotoxicity of cisplatin involves several A a r t icle mechanisms, such as the inhibition of membrane transport and adenosine triphosphatase (.lTPase) activity as well as mitochondria1 injury leading to reduced oxygen consuniption,"." and has not yet been completely elucidated. Although the proximal tubules are most severely affected, distal tubules and collecting ducts may also be damaged.' Cisplatin-related injury of the nephron is diffuse5 and may include fibrosis and chronic inflammation of interstitial tissue." Besides, it has recently been shown that cisplatininduced anemia in cancer patients is associated with a progressive erythropoietin deficiency syndrome.' Comparable levels of anemia, which we also found in our patients with and without concomitant chemotherapy, indicate hospital policy of treating anemia rather than severity of toxicity. While the level of anemia requir-