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Dialysate containing nitric oxide suppresses platelet activation on the surface of dialysis membrane

✍ Scribed by Kenichi Kokubo; Shunichiro Urabe; Sachiho Hanada; Tomoyo Ebine; Hiroshi Tsukao; Toshihiro Shinbo; Minoru Hirose; Hirosuke Kobayashi


Book ID
116791151
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
37 KB
Volume
27
Category
Article
ISSN
1089-8603

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Excessive nitric oxide (NO) generated by hepatic cells in response to lipopolysaccharide (LPS) and inflammatory substances (e.g., platelet-activating factor [PAF]) is a key contributor to the pathophysiological outcomes observed in the liver during sepsis. In rats subjected to liver-focused endotoxe