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Diagnostic work-up of inflammatory bowel disease in children: The role of calprotectin assay

✍ Scribed by A. Diamanti; F. Panetta; M.S. Basso; A. Forgione; F. Colistro; F. Bracci; B. Papadatou; P. Francalanci; F. Torroni; D. Knafelz; F. Fina; M. Castro

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 91 KB
Volume: 16
Category: Article
ISSN: 1078-0998
DOI: 10.1002/ibd.21257

No coin nor oath required. For personal study only.

✦ Synopsis

Background: Some reports highlight the potential application of fecal calprotectin as a direct biomarker of intestinal inflammation and, therefore, as support in choosing candidates for endoscopy. The value of 100 lg/g was recently assumed as the best cutoff for this assay. The purpose of this study was to assess the diagnostic precision of the fecal calprotectin assay, compared to histology, as a stool-screening biomarker for inflammatory bowel disease (IBD) among a group of prospectively identified patients referred for recurrent abdominal pain and altered bowel habits.

Methods: Between 1999 and 2007 we prospectively evaluated the calprotectin assay in a cohort of patients with recurrent abdominal pain and altered bowel habits associated or not with other symptoms suggestive of IBD. All patients suspected of IBD, according to Rome and Porto criteria, provided stool specimens for the calprotectin assay and subsequently underwent endoscopic procedures.

Results: Compared to histology, the cutoff of 100 lg/g reached a sensitivity and specificity of 100% and 68%, respectively, and a likelihood ratio (LR) of 3.1. The cutoff value of 160 lg/g, however, in our series produced the best joint estimate of sensitivity and specificity: 100% and 80%, respectively, with an LR of 5.

Conclusions:

In pediatric patients with recurrent abdominal pain and changes in stool habits, a positive calprotectin assay is closely associated with IBD; its systematic employment, therefore, seems to improve the process of endoscopy referral. This test, simple and inexpensive, could be included in the first noninvasive phase of an IBD diagnostic work-up.

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