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Diagnostic value of the oral glucose tolerance test evaluated with a mathematical model

✍ Scribed by L. Jansson; L. Lindskog; N.E. Nordén; S. Carlström; B. Scherstén

Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
591 KB
Volume
13
Category
Article
ISSN
0010-4809

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✦ Synopsis

The dynamics of the blood glucose concentration during the oral glucose tolerance test are different from normal in at least 96% of patients with diabetes mellitus. This is shown by using stepwise linear discriminant analysis and a mathematical model of the glucose homeostasis for the analysis of the glucose curves in 378 cases. The mathematical model gives an estimate of the rate of intestinal glucose resorption and this information was used to significantly improve the discrimination between diabetes meilitus and the normal state. The same estimate was also useful for the detection of oxyhyperglycemia and malabsorption. The effect of age on the glucose tolerance was included in the discriminant analysis. The intra-individual biological variation in cases with borderline glucose tolerance was found to be 11%.

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