✦ LIBER ✦

Diagnostic value of anti-HBc IgM in high hbv prevalence areas

✍ Scribed by George Papaevangelou; Anastasia Roumeliotou-Karayannis; Nicolaos Tassopoulos; Paraskevi Stathopoulou

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 447 KB
Volume: 13
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890130411

No coin nor oath required. For personal study only.

✦ Synopsis

The diagnostic value of an anti-mu-capture immunoassay for the detection of IgM antibody against hepatitis B core antigen (anti-HBc) was evaluated. Strongly positive results were obtained from the acute phase sera of the 25 acute hepatitis B patients who were hepatitis B surface antigen (HBsAg) positive and of the 18 confirmed acute hepatitis B patients who had already cleared HBsAg when symptoms developed. Negative results were obtained in 5 hepatitis A patients, 20 non-A, non-B acute hepatitis patients serologically susceptible to HBV, 22 patients with chronic hepatitis B liver disease, 15 asymptomatic HBsAg carriers, and 10 healthy patients immune from past HBV infection. Fourteen of the acute hepatitis patients remained HBsAg positive for a follow-up period of at least 6 months, and 12 of these were found consistently anti-HBc IgM negative. These were considered as chronic HBsAg carriers with a superimposed form of acute liver injury. These data show that this assay can differentiate between acute from chronic (HBsAg positive) and recent from old (HBsAg negative) hepatitis B virus infection. Thus, it should be very useful in the complex diagnostic situations encountered commonly in areas with high prevalence of HBV infections.

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