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Diagnostic Approach and Management of Lynch Syndrome (Hereditary Nonpolyposis Colorectal Carcinoma): A Guide for Clinicians

✍ Scribed by Dr. Yvonne M.C. Hendriks; Dr. Andrea E. de Jong; Prof. Hans Morreau; Dr. Carli M.J. Tops; Dr. Hans F. Vasen; Dr. Juul Th. Wijnen; Prof. Martijn H. Breuning; Dr. Annette H.J.T. Bröcker-Vriends


Book ID
115070740
Publisher
American Cancer Society
Year
2006
Tongue
English
Weight
811 KB
Volume
56
Category
Article
ISSN
0007-9235

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Hereditary nonpolyposis colorectal carcinoma (HNPCC) is the most common hereditary form of colorectal carcinoma (CRC) and may account for 5-10% of the total CRC burden. The discovery of DNA mismatch repair (MMR) genes, inclusive of hMSH2, hMLH1, hPMS2, and hMSH6, has enabled the identification of wh