Diagnostic and prognostic validity of the human papillomavirus E6/E7 mRNA test in cervical cytological samples of HC2-positive patients
β Scribed by Maria Benevolo; Irene Terrenato; Marcella Mottolese; Ferdinando Marandino; Mariantonia Carosi; Francesca Rollo; Livia Ronchetti; Paola Muti; Luciano Mariani; Stefano Sindico; Giuseppe Vocaturo; Amina Vocaturo
- Book ID
- 106383266
- Publisher
- Springer Netherlands
- Year
- 2011
- Tongue
- English
- Weight
- 172 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0957-5243
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## BACKGROUND. Human papillomaviruses (HPV) are the most important etiologic factor for cervical carcinoma. However, additional cellular events may be necessary for malignant progression in the cervix. Recently, the fragile histidine triad (FHIT) gene, which is frequently lost in many cancers, was
Tissue from I I cases of cervical cancer positive for human papillomavirus (HPV) type I 6 DNA and 69 pelvic lymph nodes from the same patients were examined for HPV 16 DNA and mRNA from the E6/E7 genes. Five of the tumors were squamom, 3 adeno-and 3 adenosquamous carcinoma. From the primary tumors a