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Diagnostic and prognostic significance of t(1;3)(p36;q21) in the disorders of hematopoiesis

✍ Scribed by Jeanna L. Welborn; Jerry P. Lewis; Helen Jenks; Paula Walling

Book ID
119103582
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
383 KB
Volume
28
Category
Article
ISSN
0165-4608

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The reciprocal translocation t(1;3)(p36;q21) is associated with myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML) characterized by trilineage dysplasia, in particular dysmegakaryocytopoiesis, and a poor prognosis. As yet no molecular genetic analyses of the t(1;3) have been reported.

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## Abstract The recurrent translocation t(1;3)(p36;q21) is associated with myelodysplastic syndrome (MDS)/acute myelogenous leukemia (AML) characterized by trilineage dysplasia, especially dysmegakaryopoiesis and a poor prognosis. Recently, the two genes involved in this translocation have been ide