Diagnosis of Pelizaeus–Merzbacher disease: detection of proteolipid protein gene copy number by real-time PCR
✍ Scribed by Stefano Regis; Serena Grossi; Susanna Lualdi; Roberta Biancheri; Mirella Filocamo
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 247 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1364-6745
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
We report the development of a method for diagnosis of heterozygous deletions or duplications based on measurement of gene copy number. The method involves amplifications of a test locus with unknown copy number and a reference locus with known copy number using real-time PCR. Progress of the PCR re
## Abstract Increased __MYCN__ gene copy number is a characteristic property of neurogenic tumors. Fluorescence in situ hybridization (FISH) and array‐based comparative genomic hybridization (array‐CGH) are traditionally used to determine __MYCN__ amplification for tumor stratification. A unique ab