Diagnosis and treatment of fungal infections in patients with hematologic malignancies

✍ Scribed by F. Radaelli; A. Cortelezzi; L. Zocchi; D. Castagnone; L. Baldini; M. Colombi; R. Mozzana

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 442 KB
• Volume: 4
• Category: Article
• ISSN: 0278-0232
• DOI: 10.1002/hon.2900040205

✦ Synopsis

A diagnosis of deep-seated mycosis was made in 54 patients with hematologic malignancies, severe neutropenia and fever, based on a set of clinical and laboratory criteria. Standardized antifungal treatment was started in 31 patients who seven days after onset of fever had not responded to antibiotics; the fungal infection was cured in 13, all of whom had a simultaneous remission of neutropenia, whereas the other 18 who did not respond to antifungal treatment, all had a falling or static neutrophil count. None of the 23 patients who were given no or inadequate antifungal treatment survived regardless of the neutrophil count and/or phase of the hematologic disease. We discuss the suitability of utilizing empirical criteria for a diagnosis of disseminated fungal infection as a basis for starting antifungal therapy in this type of patient.