Diagnosis and treatment of epstein-barr virus-associated natural killer cell lymphoproliferative disease
✍ Scribed by Keisei Kawa
- Book ID
- 105675724
- Publisher
- Carden Jennings Publishing
- Year
- 2003
- Tongue
- English
- Weight
- 134 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0925-5710
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Lymphoproliferative disorder of natural killer cells is a heterogeneous disorder, and an association with Epstein-Barr virus (EBV) is suggested in some cases. A Japanese male presenting with recurrent nasopharyngeal problems developed fever, generalized lymphadenopathy, and hepatosplenomegaly. Separ
## Abstract Epstein–Barr virus (EBV)‐associated B‐cell lymphoproliferative disease may be polyclonal, oligoclonal, or monoclonal. The degree of tumor clonality reflects the disease pathogenesis and may have implications for disease diagnosis, prognosis, and treatment. In this study, specimens of EB
EBV infects B lymphocytes in vivo and establishes a life-long persistent infection in the host. The latent infection is controlled by EBV-specific MHC class 1-restricted CTL. Immunosuppression reduces CTL activity, and this facilitates outgrowth of EBV+ve B cell lymphoproliferative disease (BLPD). B