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Diagnosis and management of trimethylaminuria (FMO3 deficiency) in children

✍ Scribed by R. A. Chalmers; M. D. Bain; H. Michelakakis; J. Zschocke; R. A. Iles

Publisher
Springer
Year
2006
Tongue
English
Weight
426 KB
Volume
29
Category
Article
ISSN
0141-8955

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The mammalian flavin-containing monooxygenases catalyze the NADPH-dependent N-oxygenation of nucleophilic nitrogen-, sulfur-, and phosphorus-containing chemicals, drugs, and xenobiotics, including trimethylamine. The FMO3 gene encodes the dominant catalytically active isoform present in human liver.