Seventy-six aortic and mitral valves, in 44 patients and 5 normal volunteers, were studied by Cine-Flow MRI (on a0.26-T superconducting magnet system), utilizingcompound oblique imaging planes and a Field Echo Even Rephasing sequence. All patients had had cardiac catheterization and echocardiography. All patients with valvular stenosis and aortic sclerosis ( n = 45) showed complete signal loss distal to the respective valve.
Length of signal loss distal to the aortic valve in those in whom it was measured ( n = 15) allowed differentiation of aortic stenosis ( n = 9) from sclerosis ( n = 6). This also permitted grading of stenosis with highly significant correlation ( T = 0.86; P < 0.002) with pressure gradient measurement. In mitral stenosis ( n = 12) calculation of the area of signal loss distal to the mitral valve as a percentage of left ventricular cross-sectional area showed a highly significant correlation ( T = 0.77; P = 0.001) with pressure gradient measurement. Clinically significant valvular regurgitation was graded by size and duration of signal loss proximal to the valve with concordance with angiocardiography. It is concluded that Cine-Flow MRI has a clinical role in the diagnosis and assessment of valvular heart disease.