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Diacylglycerols, unlike phorbol esters, do not induce homologous desensitization or down-regulation of protein kinase C in Swiss 3T3 cells

โœ Scribed by Marc Issandou; Enrique Rozengurt


Book ID
115762144
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
704 KB
Volume
163
Category
Article
ISSN
0006-291X

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Homologous desensitization of bombesin-i
โœ John H. Walsh; Mark Bouzyk; Enrique Rozengurt ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 856 KB

Addition of bombesin to Swiss 3T3 cells causes a rapid and transient increase in the intracellular concentration of Ca2+ ([Ca'+li), which is followed by desensitization to a subsequent addition of the peptide. The concentrations of bombesin used to study this acute cellular desensitization (0.1-0.5