Diacylglycerols and mezerein activate neutrophils by a phorbol myristate acetate-like mechanism

✍ Scribed by Joseph T. O'Flaherty; Jimmy F. Redman Jr.; Charles E. McCall; Robert L. Wykle; Jeffery D. Schmitt

• Book ID: 102880488
• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 808 KB
• Volume: 125
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1041250204

✦ Synopsis

rac-l-O-Myristoyl-2-O-acetylglycerol, rac-l-O-palmitoyl-2-O-acetylglycerol, and rac-I-0-oleoyl-2-0-acetylglycerol acted like phorbol myristate acetate and mezerein in stimulating human neutrophil aggregation. Responses to these agents were equally influenced by cytochalasin B, extracellular calcium and magnesium, arachidonate antimetabolites, and procedures that rendered the cells desensitized to other agonists. The compounds also inhibited the bind- ing of [3H]-phorbol myristate acetate to its receptor on neutrophils. Thus, these agents are biologically homologous. They act by binding to a common receptor. This receptor may function physiologically as a transducer for e ndogenous glycerides that form in cells challenged by other stimuli.