β Scribed by Irina G. Obrosova; Stephen S. M. Chung; Peter F. Kador
No coin nor oath required. For personal study only.
Diabetes mellitus is associated with a 5βfold higher prevalence of cataracts, which remains a major cause of blindness in the world. Typical diabetic cataracts contain cortical and/or posterior subcapsular opacities. Adult onset diabetic cataracts also often contain nuclear opacities. Mechanisms of diabetic cataractogenesis have been studied in less detail than those of other diabetic complications. Both animal and human studies support important contribution of increased aldose reductase activity. Surgical extraction is the only cure of diabetic cataract today. An improved understanding of pathogenetic mechanisms, together with finding effective therapeutic agents, remain highest priority for diabetic cataractβrelated research and pharmaceutical development. Copyright Β© 2010 John Wiley & Sons, Ltd.
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