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Diabetes mellitus associated with the 3243 mitochondrial tRNALeu(UUR) mutation: Insulin secretion and sensitivity

✍ Scribed by Yoshihiko Suzuki; Takashi Iizuka; Tetsuro Kobayashi; Tetsuo Nishikawa; Yoshihito Atsumi; Takashi Kadowaki; Yoshitomo Oka; Hiroko Kadowaki; Matsuo Taniyama; Kazuhiro Hosokawa; Takayuki Asahina; Kempei Matsuoka

Book ID: 117180422
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 502 KB
Volume: 46
Category: Article
ISSN: 1532-8600
DOI: 10.1016/s0026-0495(97)90272-9

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The mitochondrial DNA tRNA Leu(UUR) A to G 3243 mutation is associated with maternally inherited diabetes in Caucasians and Japanese. In a Hong Kong Chinese population we have detected the 3243 mutation in 2 of 74 unrelated subjects with well characterized insulin-dependent (Type 1) diabetes mellitu