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Diabetes and Tumor Formation in Transgenic Mice Expressing Reg I

✍ Scribed by Takashi Yamaoka; Kenji Yoshino; Taketo Yamada; Chiyoko Idehara; Mohammad O. Hoque; Maki Moritani; Katsuhiko Yoshimoto; Jun-ich Hata; Mitsuo Itakura


Book ID
115586893
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
554 KB
Volume
278
Category
Article
ISSN
0006-291X

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Transgenic mice harboring the early genome from the human neurotropic JC virus, JCV, develop massive abdominal tumors of neural crest origin during 6-8 months after birth and succumb to death a few weeks later. The viral early protein, T-antigen, which possesses the ability to transform cells of neu