DHPLC analysis of potassium ion channel genes in congenital long QT syndrome

✍ Scribed by Roselie Jongbloed; Carlo Marcelis; Crool Velter; Pieter Doevendans; Joep Geraedts; Hubert Smeets

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 58 KB
• Volume: 22
• Category: Article
• ISSN: 1059-7794
• DOI: 10.1002/humu.10293

✦ Synopsis

The original article to which this Erratum refers was published in Human Mutation 20:382-391 (2003) The following errors were noticed in the original version of this article in Tables 4 and5 and in the section Results, subsections '' Analysis of KCNQ1'' and '' Analysis of KCNH2''. Within the manuscript all mutations were described according the nomenclature as described by Den Dunnen and Antonarakis (2000). Table 4. Pathogenic Mutations Identified by DHPLC Analysis KCNQ1 1557G4A -the correct nucleotide number is c.1669G4A KCNH2 582-587delCCGTG -the correct nucleotide number is c.578 _ 582delCCGTG KCNH2 1501A4G -the correct nucleotide change is c.1501G4A KCNH2 2471insG; Arg823fs828 -the correct coding effect is p.Leu824fs828 Table 5. Single Nucleotide Polymorphisms (SNPs) Identified in the KCNQ1, KCNH2, KCNE1 and KCNE2 Genes KCNH2 IVS2+27g4c -the correct location of the SNP is IVS2 þ 22G4C Erratum received