DFT Study on Tautomerism of Dihydro-2H-1,5-benzodiazepin-2-ones and Dihydro-2H-1,5-benzodiazepine-2-thiones
✍ Scribed by Sergiy I. Okovytyy; Liudmyla K. Sviatenko; Alexandr A. Gaponov; Liliya I. Kasyan; Igor N. Tarabara; Jerzy Leszczynski
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 786 KB
- Volume
- 2010
- Category
- Article
- ISSN
- 1434-193X
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## Abstract 2a,4‐Disubstituted 5‐benzoyl‐2‐chloro/2,2‐dichloro‐2a,3,4,5‐tetrahydro‐azeto [1,2‐a] [1,5]benzodiazepin‐1 (2H)‐ones (**3a–h**) were synthesized by cycloaddition reactions of 2,4‐disubstituted 1‐benzoyl‐2,3‐dihydr o‐1__H__‐1,5‐benzodiazepines (**2a–h**) and ketenes, generated from chloro
## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbon‐14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^C‐benzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des