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Dextromethorphan to dextrorphan: a pathway towards abuse liability

✍ Scribed by Shannon C. Miller


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
40 KB
Volume
26
Category
Article
ISSN
0885-6222

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## Abstract Dextromethorphan is used as a probe drug for assessing CYP2D6 and CYP3A4 activity __in vivo__ and __in vitro__. A SIM GC/MS method without derivatization for the simultaneous determination of dextromethorphan and its metabolites, dextrorphan, 3‐methoxymorphinan and 3‐hydroxymorphinan, i