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Dextromethorphan-induced near-fatal suicide attempt in a slow metabolizer at cytochrome P450 2D6

✍ Scribed by Nadia Matin; Amit Kurani; Cheryl A. Kennedy; Qin-Yue Liu

Book ID
116213416
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
335 KB
Volume
5
Category
Article
ISSN
1543-5946

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Metabolism of Dextromethorphan in vitro:
Metabolism of Dextromethorphan in vitro: Involvement of Cytochromes P450 2D6 AND 3A3/4, with a Possible Role of 2E1
✍ JÜRGEN SCHMIDER; DAVID J. GREENBLATT; STEVEN M. FOGELMAN; LISA L. VON MOLTKE; RI πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 191 KB πŸ‘ 1 views

Dextromethorphan (DMO), a cough suppressing synthetic analog of codeine, undergoes parallel O-demethylation to dextrorphan (DOP), and N-demethylation to 3-methoxymorphinan (MEM), in humans. 3-hydroxymorphinan, a didemethylated metabolite, is formed secondarily. O-demethylation activity is well estab