Plasma pharmacokinetics and tissue dispo
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Suman Penugonda; Hitesh K. Agarwal; Keykavous Parang; Reza Mehvar
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Article
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2010
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John Wiley and Sons
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English
⚖ 165 KB
The plasma and tissue disposition of two novel dextran prodrugs of methylprednisolone (MP) containing one (DMP-1) or five (DMP-5) amino acids as linkers were studied in rats. Single 5-mg/kg doses (MP equivalent) of each prodrug or MP were administered intravenously, and blood and tissue samples were