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Dextran–methylprednisolone succinate as a prodrug of methylprednisolone: Plasma and tissue disposition

✍ Scribed by Xiaoping Zhang; Reza Mehvar


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
165 KB
Volume
90
Category
Article
ISSN
0022-3549

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Plasma pharmacokinetics and tissue dispo
✍ Suman Penugonda; Hitesh K. Agarwal; Keykavous Parang; Reza Mehvar 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 165 KB

The plasma and tissue disposition of two novel dextran prodrugs of methylprednisolone (MP) containing one (DMP-1) or five (DMP-5) amino acids as linkers were studied in rats. Single 5-mg/kg doses (MP equivalent) of each prodrug or MP were administered intravenously, and blood and tissue samples were