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Dextran sulphate sodium induces acute colitis and alters hepatic function in hamsters

✍ Scribed by Agneta Karlsson; Åke Jägervall; Madeleine Pettersson; Ann-Katrin Andersson; Per-Göran Gillberg; Silvia Melgar

Book ID
116576272
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
644 KB
Volume
8
Category
Article
ISSN
1567-5769

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P-glycoprotein (P-gp), the product of the multiple drug resistance (mdr) gene, can actively pump toxic drugs out of cells, but its pathophysiologic role is not yet fully understood. In this study, we examined the expression of P-gp in dextran sodium sulfate (DSS)-induced colitis in mice. Eight-week-