Dexrazoxane exposure and risk of secondary acute myeloid leukemia in pediatric oncology patients
โ Scribed by Seif, Alix E.; Walker, Dana M.; Li, Yimei; Huang, Yuan-Shung V.; Kavcic, Marko; Torp, Kari; Bagatell, Rochelle; Fisher, Brian T.; Aplenc, Richard
- Book ID
- 126559799
- Publisher
- John Wiley and Sons
- Year
- 2014
- Tongue
- English
- Weight
- 237 KB
- Volume
- 62
- Category
- Article
- ISSN
- 1545-5009
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## Abstract ## BACKGROUND Significantly elevated telomerase activity (TA) has been found in samples from patients with almost all malignant hematologic diseases. The impact of elevated TA on the course of pediatric patients with acute myeloid leukemia (PโAML) is unknown. ## METHODS Using a modif
Mutations at codon I 2, I 3, and 6 I of the HRAS, KRAS, and NRASgenes were evaluated in 99 cases of pediatric acute myeloid leukemia (AML) using oligonucleotide hybridization to polymerase chain reacted derived products. Twenty-four mutations were identified in the NRAS gene, I 3 in the KRAS gene, a