Dexfenfluramine for weight gain secondary to psychotropics

✍ Scribed by Prakash S. Masand; Sanjay Gupta

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 55 KB
• Volume: 6
• Category: Article
• ISSN: 1091-4269
• DOI: 10.1002/(sici)1520-6394(1997)6:3<119::aid-da5>3.0.co;2-8

✦ Synopsis

We describe the use of dexfenfluramine (Redux) in six patients with mood disorders (bipolar disorder = 3; major depression = 3) who developed significant weight gain as a result of their psychotropics. All patients were females with an age range of 27-58 years. The duration of the trial varied from 3 to 20 weeks, with the dexfenfluramine dosage being 15 mg twice daily. Weight loss ranged from 2 to 23 pounds. None of the patients had any evidence of primary pulmonary hypertension or serotonin syndrome, despite being on serotonergic agents such as fluoxetine, paroxetine, and sertraline. Depression and Anxiety

6:119-123, 1997.