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Dexamethasone suppression test in dementia

✍ Scribed by M. T. Abou-Saleh; E. M. Spalding; J. M. Kellett; A. Coppen


Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
592 KB
Volume
2
Category
Article
ISSN
0885-6230

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✦ Synopsis


The performance of the Dexamethasone Suppression Test (DST) was investigated in 60 demented patients including 14 patients admitted to a psychogeriatric assessment ward, 29 electively admitted patients and 17 long-stay patients in comparison with 37 normal control subjects. It was shown that acutely admitted patients had the highest rate of DST non-suppression (86%), whilst electively admitted patients had the lowest rate (55%) in comparison with normal controls (11%). In the electively admitted group abnormal DST results and Cortisol Suppression Index and DST non-suppressors showed depressive signs more frequently than suppressors. There was no association between DST results and age, weight, cognitive, behavioural, cortical dysfunction and degree of cerebral atrophy as determined by CT scan results. KEY woms-Dexamethasone suppression test, Dementia.


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## Abstract The Dexamethasone Suppression Test (DST), supposed to effectively distinguish between endogenous and nonendogenous depression, was performed in a group of 34 patients with Parkinson's disease. Abnormal DST results were observed in 50% of the patients. The patients were clinically divide