Lonidamine (LND), a selective inhibitor of the energy metabolism of tumor cells, induces apoptosis, independently of the p53 gene, in the adriamycin(ADR)-resistant MCF7 breast-cancer cell line (MCF7 ADR). On the contrary, LND fails to activate the apoptotic program in the parental MCF7-sensitive cel
Dexamethasone inhibits TNF-α-induced apoptosis and IAP protein downregulation in MCF-7 cells
✍ Scribed by Udo K Messmer; Carmen Pereda-Fernandez; Markus Manderscheid; Josef Pfeilschifter
- Book ID
- 110005715
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 370 KB
- Volume
- 133
- Category
- Article
- ISSN
- 0007-1188
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## Background The biochemical bases for hormone dependence in breast cancer have been recognized as an important element in tumor resistance, proliferation and metastasis. On this respect, dexamethasone (Dex) dependent protection against TNF-alpha-mediated cell death in the MCF-7 cell line has been