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Dexamethasone Induces Bisallylic Hydroxylation of Polyunsaturated Fatty Acids by Rat Liver Microsomes

✍ Scribed by Lena Hörnsten; Johan Bylund; Ernst H. Oliw

Book ID
115566172
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
166 KB
Volume
332
Category
Article
ISSN
0003-9861

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Polyunsaturated fatty acids (PUFAs) can be oxygenated by mammalian hepatic P450s to a series of metabolites. The most prominent of these are formed by omega- and (omega-1)-hydroxylation, epoxidation of the double bonds or bisallylic hydroxylation. The object of the present investigation was to deter