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Dexamethasone improves vascular hyporeactivity induced by LPS in vivo by modulating ATP-sensitive potassium channels activity

✍ Scribed by R D'Emmanuele Di Villa Bianca; L Lippolis; G Autore; A Popolo; S Marzocco; L Sorrentino; A Pinto; R Sorrentino


Book ID
110007940
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
179 KB
Volume
140
Category
Article
ISSN
0007-1188

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Modulation of ATP-sensitive potassium ch
✍ C. G. Nichols; E. Niggli; W. J. Lederer πŸ“‚ Article πŸ“… 1990 πŸ› Springer 🌐 English βš– 355 KB

We have used 'caged-ATP' to investigate the kinetic behavior of KATP channels in ventricular cells from rat heart. In whole cells, loaded with 'caged-ATP', an increase of intracellular [ATP] following a UV light flash produced a decrease of KATP channel current that was too slow (tau approximately 3