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Device for sterile online measurement of the oxygen transfer rate in shaking flasks

✍ Scribed by Tibor Anderlei; Jochen Büchs

Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
609 KB
Volume
7
Category
Article
ISSN
1369-703X

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✦ Synopsis

The oxygen transfer rate (OTR) is the most suitable measurable parameter to quantify the physiological state of a culture of aerobic microorganisms since most metabolic activities depend on oxygen consumption. Online measurement of the oxygen transfer rate in stirred bioreactors is state of the art although technically difficult. However, the online determination of the oxygen transfer rate in shaking bioreactors under sterile conditions has not been possible until recently. A newly developed measuring device eliminates this deficit. Extremely useful information about cultivating conditions and the physiological state of microorganisms can be gained in early stages of research and bioprocess development from many reactors operated in parallel.

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