Developmental toxicity of mono-n-benzyl phthalate, one of the major metabolites of the plasticizer n-butyl benzyl phthalate, in rats
β Scribed by Makoto Erna; Akira Harazono; Emiko Miyawaki; Yoshiyuki Ogawa
- Book ID
- 118412206
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 575 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0378-4274
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The objective of this study was to determine the susceptible day for the developmental toxicity of butyl benzyl phthalate (BBP) by a single administration on one of the days during organogenesis. Pregnant rats were given a single dose of BBP by gastric intubation at a dose of 1000 mg kg(-1) on one o
The teratogenicity of butyl benzyl phthalate (BBP) was studied in Wistar rats. Pregnant rats were given BBP at a dosage of 0, 0.25, 0.5, 1.0 or 2.0% in the diet from day 0 to day 20 of pregnancy. Daily intakes of BBP were 185 mg kg-' for the 0.25% group, 375 mg kg-' for the 0.5% group, 654 mg kg-' f
The objective of the present study was to determine if periods of exposure would modify the developmental toxicity of butyl benzyl phthalate (BBP). Pregnant Wistar rats were given BBP at a dose of 2.0% in the diet on days 0-20, days 0-7, days 7-16 or days 16-20 of pregnancy. Food consumption and bod