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Developmental toxicity of indium in cultured rat embryos

✍ Scribed by Mikio Nakajima; Masanori Sasaki; Youshiro Kobayashi; Yasuo Ohno; Makoto Usami

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
16 KB
Volume
19
Category
Article
ISSN
0270-3211

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✦ Synopsis

Developmental toxicity of indium was examined using rat embryo culture with reference to toxicokinetics. Rat embryos at day 9.5 of pregnancy were cultured for 48 h under various exposure conditions to indium trichloride. Indium was embryotoxic to cultured rat embryos at concentrations ranging from 25 to 50 Β΅M for 24 h exposure according to the embryonic age, and the exposure concentration was more critical than the exposure time. The embryotoxic concentrations were comparable to the serum concentration at a developmentally toxic dose by intravenous administration in an in vivo experiment. It was considered from these results that the developmental toxicity of indium is a direct effect on the embryo or yolk sac and that weak developmental toxicity of indium by oral administration was due to low exposure concentrations in the embryo.

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