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Developmental regulation of Notch signaling genes in the embryonic pituitary: Prop1 deficiency affects Notch2 expression

โœ Scribed by L.T Raetzman; S.A Ross; S Cook; S.L Dunwoodie; S.A Camper; P.Q Thomas


Book ID
116974776
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
938 KB
Volume
265
Category
Article
ISSN
0012-1606

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Gain-of-function mutations in Notch-1 are common in T-cell lymphoblastic leukemia (T-ALL), making this receptor a promising target for drugs such as gamma-secretase inhibitors (GSIs). However, GSIs seem to be active in only a small fraction of T-ALL cell lines with constitutive Notch-1 activity and