𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Developmental regulation of insulin like growth factor II expression in the horse.

✍ Scribed by Karina Joujou-Sisic; Marika Granérus; Hanna Wetterling; Katarina Wikström; Wilhelm Engström; Leo Jeffcott; Paul N. Schofield; Amanda Welin

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
257 KB
Volume
17
Category
Article
ISSN
1065-6995

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The expression of the insulin like growth factor (IGF) II gene has been examined in the developing equine fetus. It was found that IGF II transcripts were present in abundant quantities in third trimester embryonic and extraembryonic tissues as for example the placenta. The expression of the IGF II gene was high in the fetal liver where two prominent transcripts — 4.6 and 4.1 — kB were produced. However, these transcripts could not be traced in the adult liver. Instead we found two different transcripts with the sizes of 4.0 and 2.9 kB in the adult liver. These findings taken together with the demonstration of heterologous IGF II cDNA hybridizing to equine DNA‐digests suggests that the IGF II gene is under developmental control in the horse, with the possible existence of different promoters.

📜 SIMILAR VOLUMES

Growth factor regulation of insulin-like
Growth factor regulation of insulin-like growth factor binding protein-6 expression in osteoblasts
✍ Bari Gabbitas; Ernesto Canalis 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 238 KB 👁 2 views

Previously we have shown that transforming growth factor b (TGF b) 1, basic fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF) BB inhibit the synthesis of insulin-like growth factor (IGF) II, but their effects on IGF binding protein (IGFBP)-6 in osteoblast cultures are not kno

Insulin-like growth factor family in mal
Insulin-like growth factor family in malignant haemangiopericytomas: the expression and role of insulin-like growth factor I receptor
✍ Paveli?, Kre?imir; Paveli?, Zlatko P.; Cabrijan, Tomislav; Karner, Ivan; Samar?i 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 235 KB 👁 2 views

Haemangiopericytoma is a rare soft tissue tumour originating from the contractile pericapillary cells. Relatively little is known about its molecular pathogenesis. To address this issue, the insulin-like growth factor family (IGFs) was analysed in 19 tumours collected from a human tumour bank networ

Expression and regulation of the insulin
Expression and regulation of the insulin-like growth factor axis components in rat liver myofibroblasts
✍ Ruslan Novosyadlyy; Kyrylo Tron; Jozsef Dudas; Giuliano Ramadori; Jens-Gerd Scha 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 309 KB 👁 1 views

## Abstract Apart from hepatic stellate cells (HSC), liver myofibroblasts (MF) represent a second mesenchymal cell population involved in hepatic fibrogenesis. The IGF system including the insulin‐like growth factors I and II (IGF‐I, ‐II), their receptors (IGF‐I receptor, IGF‐IR; IGF‐II/mannose 6‐p

Role of insulin-like growth factor-I in
Role of insulin-like growth factor-I in regulating estrogen receptor-α gene expression
✍ Adriana Stoica; Miguel Saceda; Amina Fakhro; Michael Joyner; Mary Beth Martin 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 170 KB 👁 1 views

The role of insulin-like growth factor-I (IGF-I) in regulating estrogen receptor-␣ (ER-␣) gene expression and activity was investigated in the human breast cancer cell line MCF-7. Treatment of cells with 40 ng/ml IGF-I resulted in a 60% decrease in ER-␣ protein concentration by 3 h, and the amount o