Developmental regulation of immune system gene rearrangement

✍ Scribed by Howard Cedar; Yehudit Bergman

• Publisher: Elsevier Science
• Year: 1999
• Tongue: English
• Weight: 98 KB
• Volume: 11
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952-7915(99)80012-0

✦ Synopsis

Rearrangement of antigen receptors in the immune system is mediated through the action of complex enhancers which function in both a developmentally stage-specific and a cell-type-specific manner to demethylate DNA, open chromatin structure and tether the recombination machinery to one preferred allele at each locus.