Developmental plasticity of the hypoxic ventilatory response in rats induced by neonatal hypoxia
β Scribed by R. W. Bavis; E. B. Olson Jr; E. H. Vidruk; D. D. Fuller; G. S. Mitchell
- Book ID
- 110112715
- Publisher
- Cambridge University Press
- Year
- 2004
- Tongue
- English
- Weight
- 282 KB
- Volume
- 557
- Category
- Article
- ISSN
- 0022-3751
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The purpose of the study was to determine whether an episode of anoxia in the neonatal period affects the hypoxic ventilatory response in developing rats. Three to 4 day old rats (EXP rats) (day 0 = day of birth) were exposed to 100% N 2 for about 20 min. In anoxia, animals changed their respiratory
## Abstract The iron chelator desferrioxamine (DFO) induces accumulation of the hypoxiaβinducible factor (HIFβ1), a transcription factor that upβregulates genes involved in adaptative responses to hypoxia. This property makes DFO a potential neuroprotector against hypoxic stress. We investigated in