✦ LIBER ✦

Developmental pattern of expression of NPDC-1 and its interaction with E2F-1 suggest a role in the control of proliferation and differentiation of neural cells

✍ Scribed by Edmond Dupont; Isabelle Sansal; Claudine Evrard; Pierre Rouget

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 790 KB
Volume: 51
Category: Article
ISSN: 0360-4012
DOI: 10.1002/(sici)1097-4547(19980115)51:2<257::aid-jnr14>3.0.co;2-5

No coin nor oath required. For personal study only.

✦ Synopsis

We have previously identified NPDC-1, a gene specifically expressed in neural cells and involved in the control of cell proliferation and differentiation. In the present study, we have investigated the expression of this gene during mouse development and the interactions of the NPDC-1 protein with cell cycle regulatory proteins. The data show that NPDC-1 mRNA begins to be expressed in a variety of neural structures when the precursors enter into their terminal differentiation. They also indicate that in adult brain, the expression patterns of NPDC-1 and E2F-1 mRNA largely overlap. In addition, the NPDC-1 protein is able to interact directly with the transcription factor E2F-1 that participates in the regulation of the cell cycle, cell survival, and apoptosis. The present results suggest that NPDC-1 might be involved in the terminal differentiation and survival of neural cells and might act through interactions with E2F-1.

📜 SIMILAR VOLUMES

Expression of the bHLH gene NSCL-1 sugge

Expression of the bHLH gene NSCL-1 suggests a role in regulating cerebellar granule cell growth and differentiation

✍ Martine Uittenbogaard; Dena R. Peavy; Anne Chiaramello 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 423 KB 👁 3 views

We report that the neuronal-specific basic helix-loophelix (bHLH) gene NSCL-1 is expressed at multiple and distinct stages of cerebellar granule cell differentiation. During embryonic development, NSCI-1 expression is initially evenly distributed in the cerebellar primordium and then becomes restric

Functional potential of P2P-R: A role in

Functional potential of P2P-R: A role in the cell cycle and cell differentiation related to its interactions with proteins that bind to matrix associated regions of DNA?

✍ Robert E. Scott; Thomas Giannakouros; Sizhi Gao; Philippos Peidis 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 150 KB 👁 1 views

## Abstract P2P‐R is the alternately spliced product of the P2P‐R/PACT gene in that P2P‐R lacks one exon encoding 34 amino acids. The 250 kDa P2P‐R protein is the predominate product expressed in multiple murine cell lines. It is a highly basic protein that contains multiple domains including an N‐

Patterns of expression of a tumor associ

Patterns of expression of a tumor associated antigen, defined by the monoclonal antibody HMFG2, in human epithelial ovarian carcinoma. Comparison with expression of the HMFG1, AUA1, and F36/22 antigens

✍ Bruce G. Ward; David G. Lowe; John H. Shepherd 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 694 KB

The prognostic significance of prolifera

The prognostic significance of proliferation-associated nucleolar protein p120 expression in prostate adenocarcinoma : A comparison with cyclins A and B1, Ki-67, proliferating cell nuclear antigen, and p34cdc2

✍ Bhaskar V. S. Kallakury; Christine E. Sheehan; Sue J. Rhee; Hugh A. G. Fisher; R 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 355 KB 👁 2 views

In this study, the authors evaluated the prognostic significance of the expression of nucleolar antigen p120, along with other cell proliferationassociated proteins, in prostate adenocarcinomas (PACs) and compared the results with previously reported data on p34 cdc2 cyclin-dependent kinase (p34 cdk

Regulation of arachidonic acid metabolis

Regulation of arachidonic acid metabolism, aromatase activity and growth in human breast cancer cells by interleukin-1β and phorbol ester: Dissociation of a mediatory role for prostaglandin E2 in the autocrine control of cell function

✍ Robert Hughes; Pieternel Timmermans; Michael P. Schrey 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 736 KB

Analysis of the planar cell polarity gen

Analysis of the planar cell polarity gene Vangl2 and its co-expressed paralog Vangl1 in neural tube defect patients (Am J Med Genet 136A: 90–92, 2005)

✍ K. Doudney; G.E. Moore; P. Stanier; P. Ybot-Gonzalez; C. Paternotte; N.D.E. Gree 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 27 KB 👁 3 views