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Developmental features of 4-aminopyridine induced epileptogenesis

✍ Scribed by Caterina Psarropoulou; Massimo Avoli

Book ID
113253278
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
819 KB
Volume
94
Category
Article
ISSN
0165-3806

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πŸ“œ SIMILAR VOLUMES

Effect of taurine on seizures induced by
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✍ H. Pasantes-Morales; M. E. Arzate πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 English βš– 641 KB

## Abstract The effect of intraperitoneally injected taurine against the convulsive activity induced by 4‐aminopyridine (4‐AP) was studied in 12‐ to 15‐day‐old mice. At a dose of 2.6 mg/kg, taurine increased the latency of clonic seizures from 7 to 20 minutes, reduced the incidence of tonic seizure

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The K+ channel blocker 4-aminopyridine (4-AP) causes epileptiform activity in in vitro preparations and is a potent convulsant in animals and man. In mice, 4-AP produces behavioral activation, clonic limb movements and wild running, followed by tonic hindlimb extension and death (ED97, 13.3 mg/kg, s