Developmental exposure to organic lead causes permanent hippocampal damage in Fischer-344 rats
β Scribed by R. M. Booze; C. F. Mactutus
- Book ID
- 105410201
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 845 KB
- Volume
- 46
- Category
- Article
- ISSN
- 1420-682X
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Timed-pregnant Fischer 344 rats were exposed whole body to NJV-dimethylethanolamine vapor for 6 h per day on gestational days 6-15 at mean (fSD) analytically measured concentrations of 10.4 2 0.86, 29.8 f 2.14 and 100 2 4.9 ppm. Dams were sacrificed on gestational day 21. There was no maternal morta
## Abstract Chronic lead exposure during development is known to produce learning deficits. In the present study, we investigated the effects of developmental exposure to lead on spatial memory, as shown in the Morris water maze, and on expression of inducible cyclooxygenaseβ2 protein in the hippoc