Developmental changes of RNA, DNA, lipid, protein and glutamic acid decarboxylase of rat forebrain, anterior midbrain, posterior midbrain, and cerebellum
✍ Scribed by M. K. Gaitonde; Christine Tannock; Gwyneth Evans
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 613 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0360-4012
No coin nor oath required. For personal study only.
✦ Synopsis
The concentration of glutamic acid decarboxylase (/*moles of glutamic acid decarboxylated/hr/gm) was found higher in the anterior midbrain than in several other regions of the adult rat brain. It was the highest in the anterior colliculus.
posterior midbrain showed that the four regions behaved as distinct organs as regards the deposition of structural constituents and the activity of glutamic acid decarboxylase. There was evidence of postnatal cell acquisition by the four regions. The rate of accretion of DNA, RNA, phospholipid, and protein was the highest in the cerebellum, but that of glutamic acid decarboxylase was highest in the forebrain during postnatal development. The results indicated that the average size of the cerebellar cell in the adult rat was smaller than that of the cell of the forebrain, anterior midbrain, and posterior midbrain. The phospholipid content compared to that of protein was higher in the posterior midbrain than in the other three brain regions.
The presence of fully differentiated GABAergic neurons in the cerebellum appear by the end of the first postnatal week.
A developmental study of the forebrain, cerebellum, anterior midbrain, and