The development of tolerance to behavioral effects of morphine was investigated in rats that responded on a two-lever, multiple-trial, multiple differential-reinforcement-of-low-rate fixed-ratio (mult DRL FR) schedule of food presentation. Stable performances were maintained when sessions were condu
Development of tolerance to the antinociceptive effect of metergoline
โ Scribed by O. B. Fasmer; O. -G. Berge; K. Hole
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 329 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Sham and electrolytic lesions of the dorsal, median, and median + dorsal raphe nuclei were made in different groups of rats, and the differential patterns of regional 5-HT depletion were verified chemically. One week later, an initial dose-response curve for the motor impairment effect (moving belt
Furosemide was given to rats as five different i.v. bolus doses (2.5-100mg kg-I), or as an i.v. infusion to a steady-state concentration in plasma of 14pgml-'. The urinary furosemide excretion rate (AAe/At) and the diuretic effect (volume of urine) were measured. A parallel shift in the excretion-re