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Development of tolerance to the anticonvulsant effect of diazepam in dogs

✍ Scribed by Hans-Hasso Frey; Hans-Peter Philippin; Wolfgang Scheuler

Book ID
115878570
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
898 KB
Volume
104
Category
Article
ISSN
0014-2999

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Clorazepate in dogs: Tolerance to the an
Clorazepate in dogs: Tolerance to the anticonvulsant effect and signs of physical dependence
✍ R. Scherkl; Doxa Kurudi; H.-H. Frey πŸ“‚ Article πŸ“… 1989 πŸ› Elsevier Science 🌐 English βš– 660 KB

Dogs were treated with clorazepate, which is known to be completely metabolized to desmethyldiazepam. 2 mgikg t.i.d. were given orally for 5-6 weeks, a dose regimen providing plasma concentrations of desmethyldiazepam in the range known to be therapeutic in man. The rate of development of tolerance