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Development of tolerance and cross-tolerance to the cataleptogenic effects of Δ8-tetrahydrocannabinol and 11-hydroxy-Δ8-tetrahydrocannabinol in mice

✍ Scribed by Kazuhito Watanabe; Ikuo Yamamoto; Hidetoshi Yoshimura


Book ID
115877984
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
230 KB
Volume
94
Category
Article
ISSN
0014-2999

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Tolerance to the effects ofΔ9-tetrahydro
✍ Pamela F. Anderson; D. M. Jackson; G. B. Chesher; R. Malor 📂 Article 📅 1975 🏛 Springer 🌐 English ⚖ 558 KB

The onset and duration of tolerance to three effects of A9-tetrahydrocannabinol (A9-THC) given orally to mice were compared. The effects of A9-THC studied were: hypothermia, the depression of intestinal motility and the effect on spontaneous locomotor activity. When mice were dosed and tested at 24