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Development of the phagocytic and cidal capacity during maturation of myeloid cells: studies on cells from patients with chronic myelogenous leukaemia

✍ Scribed by Erik K. Segel; Jørgen Ellegaard; Niels Borregaard


Book ID
114711126
Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
644 KB
Volume
67
Category
Article
ISSN
0007-1048

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## Abstract Chronic myelogenous leukemia is caused by the acquisition of the reciprocal (9;22)(q34;q11) chromosomal translocation in hematopoietic stem cells. The fusion protein showed higher and aberrant tyrosine kinase activity. The inhibition of the tyrosine kinase activity of the protein repres