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Development of Synthetic Methodology Suitable for the Radiosynthesis of Combretastatin A-1 (CA1) and Its Corresponding Prodrug CA1P†

✍ Scribed by Shirali, Anupama; Sriram, Madhavi; Hall, John J.; Nguyen, Benson L.; Guddneppanavar, Rajsekhar; Hadimani, Mallinath B.; Ackley, J. Freeland; Siles, Rogelio; Jelinek, Christopher J.; Arthasery, Phyllis


Book ID
115438477
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
233 KB
Volume
72
Category
Article
ISSN
0163-3864

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Carbon-14 radiosynthesis of combretastat
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## Abstract The natural product combretastatin A‐1 (CA1) is isolated from the African bush willow tree, a member of the __Combretaceae__ family. CA1 has important medicinal value, due in part to its ability to inhibit tubulin assembly. The prodrug combretastatin A‐1 diphosphate (CA1P; OXi4503) is c