Development of stable formulations for PLGA/PLA microsphere vaccines
β Scribed by J.L. Cleland
- Book ID
- 117614908
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 299 KB
- Volume
- 149
- Category
- Article
- ISSN
- 0923-2494
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We have evaluated the stability profiles of adenovirus type-5 (Ad5)-based vaccine formulations to identify liquid formulations that are stable during long-term storage at 48C. By identifying the major physiochemical inactivation pathway(s) during storage, formulations of Ad5 were designed with speci
The entrapment of beta-galactosidase (Escherichia coli) in PLA and PLGA microspheres using a double emulsion technique resulted to significant reduction of protein antigenicity. The extent of antigenicity loss depended on the conditions of microsphere preparation. Most of antigenicity loss occurred