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Development of Ratiometric Fluorescent Probes for Phosphatases by Using a pKa Switching Mechanism

✍ Scribed by Shin Mizukami; Shuji Watanabe; Kazuya Kikuchi

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 227 KB
Volume: 10
Category: Article
ISSN: 1439-4227
DOI: 10.1002/cbic.200900214

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✦ Synopsis

Abstract

A novel design strategy for fluorescent probes based on a p__K__~a~ switching mechanism was developed. Using this strategy, we developed ratiometric probes for the detection of acid phosphatase activity.magnified image

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